Modulating Cholesterol Homeostasis to Build a Better T Cell

Yoko Kidani; Steven J Bensinger

doi:10.1016/j.cmet.2016.05.015

Modulating Cholesterol Homeostasis to Build a Better T Cell

Cell Metab. 2016 Jun 14;23(6):963-964. doi: 10.1016/j.cmet.2016.05.015.

Authors

Yoko Kidani¹, Steven J Bensinger²

Affiliations

¹ Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
² Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: [email protected].

PMID: 27304495
DOI: 10.1016/j.cmet.2016.05.015

Abstract

There is great interest in discovering targets for in vitro manipulation of autologous T cells that enhance their cytotoxicity against tumor targets as a potent cancer immunotherapy. In a recent Nature paper, Xu and colleagues reveal new insights into the link between cellular cholesterol metabolism and CD8 T cell functions.

Publication types

Comment

MeSH terms

Acetyl-CoA C-Acetyltransferase / metabolism
Animals
CD8-Positive T-Lymphocytes / metabolism*
Cholesterol / metabolism*
Homeostasis*
Lymphocyte Activation / immunology
Mice
Models, Biological

Substances

Cholesterol
Acetyl-CoA C-Acetyltransferase