Induction of pyroptosis in colon cancer cells by LXRβ

Cédric Rébé; Valentin Derangère; François Ghiringhelli

doi:10.4161/23723548.2014.970094

Induction of pyroptosis in colon cancer cells by LXRβ

Mol Cell Oncol. 2015 Feb 24;2(1):e970094. doi: 10.4161/23723548.2014.970094. eCollection 2015 Jan-Mar.

Authors

Cédric Rébé¹, Valentin Derangère², François Ghiringhelli³

Affiliations

¹ Institut National de la Santé et de la Recherche Médicale (INSERM); UMR 866; Dijon, France; Centre Georges François Leclerc; Dijon, France.
² Institut National de la Santé et de la Recherche Médicale (INSERM); UMR 866; Dijon, France; Faculté de Médecine et de Pharmacie; Université de Bourgogne; Dijon, France.
³ Institut National de la Santé et de la Recherche Médicale (INSERM); UMR 866; Dijon, France; Centre Georges François Leclerc; Dijon, France; Faculté de Médecine et de Pharmacie; Université de Bourgogne; Dijon, France.

Abstract

Liver X receptors (LXRs) have been proposed to have some anticancer properties. We recently identified a new non-genomic role of LXRβ in colon cancer cells. Under LXR agonist treatment, LXRβ induces pyroptosis of these cells in vitro and in vivo, raising the possibility of targeting this isoform in cancer treatment.

Keywords: Caspase-1; LXR; NLRP3 pannexin 1; colon cancer; pyroptosis.

Grants and funding

This work was supported by “Ligue contre le cancer comité Grand-Est” and by a French Government grant managed by the French National Research Agency under the program “Investissements d’Avenir”, reference ANR-11-LABX-0021 (Lipstic Labex). The FG group is “Equipe labélisée Ligue Nationale Contre le Cancer”. VD is the recipient of a “poste d’accueil INSERM”.