Pontin, a novel interactor of mutant p53 that promotes mutant p53 gain of function

Yuhan Zhao; Xuetian Yue; Wenwei Hu

doi:10.1080/23723556.2015.1076587

Pontin, a novel interactor of mutant p53 that promotes mutant p53 gain of function

Mol Cell Oncol. 2015 Jul 29;3(2):e1076587. doi: 10.1080/23723556.2015.1076587. eCollection 2016 Mar.

Authors

Yuhan Zhao¹, Xuetian Yue¹, Wenwei Hu¹

Affiliation

¹ Rutgers Cancer Institute of New Jersey, Rutgers the State University of New Jersey , New Brunswick, NJ, USA.

Abstract

Many tumor-associated mutant p53 proteins gain new activities to promote tumorigenesis, which is termed as gain of function of mutant p53 (GOF). Currently, the mechanisms of mutant p53 GOF remain elusive. We recently identified the AAA+ ATPase pontin as a critical regulator of mutant p53 GOF, thus providing a novel mechanism for mutant p53 GOF.

Keywords: Gain of function; mutant p53;pontin; tumorigenesis.

Grants and funding

R01 CA160558/CA/NCI NIH HHS/United States