Redefining the roles of apoptotic factors in carcinogenesis

Xinjian Liu; Yujun He; Fang Li; Qian Huang; Takamitsu A Kato; Russell P Hall; Chuan-Yuan Li

doi:10.1080/23723556.2015.1054550

Redefining the roles of apoptotic factors in carcinogenesis

Mol Cell Oncol. 2015 Jun 10;3(3):e1054550. doi: 10.1080/23723556.2015.1054550. eCollection 2016 May.

Authors

Xinjian Liu¹, Yujun He², Fang Li³, Qian Huang⁴, Takamitsu A Kato⁵, Russell P Hall¹, Chuan-Yuan Li⁶

Affiliations

¹ Department of Dermatology, Duke University Medical Center , Durham, NC, USA.
² Department of General Surgery, Daping Hospital, Third Military Medical University , Chongqing, China.
³ Cancer Center, First People's Hospital, Shanghai Jiaotong University, School of Medicine , Shanghai, China.
⁴ Department of Environmental and Radiological Health Sciences, Colorado State University , Fort Collins, CO, USA.
⁵ Department of Pharmacology, Duke University Medical Center , Durham, NC, USA.
⁶ Department of Dermatology, Duke University Medical Center, Durham, NC, USA; Department of Pharmacology, Duke University Medical Center, Durham, NC, USA; Department of Cancer Biology, Duke University Medical Center, Durham, NC, USA.

Abstract

In a recent study we reported that mammalian cells exposed to stress such as ionizing radiation can survive with activation of caspase-3 or caspase-7. We found that sublethal activation of the executioner caspases promotes chemical- and radiation-induced genetic instability and carcinogenesis, in contrast to their perceived roles as tumor suppressors.

Keywords: Caspase-3; carcinogenesis; endonuclease G; genetic instability.

Abstract

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