The second hit of DNA methylation

Annalisa Di Ruscio; Robert S Welner; Daniel G Tenen; Giovanni Amabile

doi:10.1080/23723556.2015.1093690

The second hit of DNA methylation

Mol Cell Oncol. 2015 Oct 29;3(3):e1093690. doi: 10.1080/23723556.2015.1093690. eCollection 2016 May.

Authors

Annalisa Di Ruscio¹, Robert S Welner², Daniel G Tenen³, Giovanni Amabile⁴

Affiliations

¹ Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA; Department of Translational Medicine, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.
² Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA.
³ Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA; Cancer Science Institute, National University of Singapore, Singapore.
⁴ Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA; ADIENNE, Lugano, Switzerland.

Abstract

Gene expression programs are tightly regulated by heritable "epigenetic" information, which is stored as chemical modifications of histones and DNA. With the recent development of sequencing-based epigenome mapping technologies and cancer cellular reprogramming, the tools are now in hand to analyze the epigenetic contribution to human cancer.

Abstract

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