Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists

Affiliations

• ¹ Department of Chemistry and Institute of Medicinal Chemistry, East China Normal University , 3663 North Zhong Shan Road, Shanghai 200062, China.
• ² Laboratory of Receptor-Based BioMedicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University , 1239 Siping Road, Shanghai 200092, China.
• ³ State Key Laboratory of Drug Research, The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 189 Guoshoujing Road, Shanghai 201203, China.
• ⁴ CAS Key Laboratory of Receptor Research, The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 189 Guoshoujing Road, Shanghai 201203, China.
• ⁵ Laboratory of Receptor-Based BioMedicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China; CAS Key Laboratory of Receptor Research, The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guoshoujing Road, Shanghai 201203, China.