Tunable P-Chiral Bisdihydrobenzooxaphosphole Ligands for Enantioselective Hydroformylation

Org Lett. 2016 Jul 15;18(14):3346-9. doi: 10.1021/acs.orglett.6b01452. Epub 2016 Jun 22.

Abstract

Air-stable and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were employed in rhodium-catalyzed asymmetric hydroformylation of various terminal olefins with excellent conversions (>99%), moderate-to-excellent enantioselectivities (up to 95:5 er), and branched to linear ratios (b:l) of up to 400.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.