Abstract
Revascularization of infrainguinal peripheral artery disease has traditionally been accomplished via percutaneous transluminal angioplasty. However, long-term results have been hampered by high rates of restenosis. Along with the advent of stents, paclitaxel-coated balloons are an emerging therapeutic option for the invasive management of infrainguinal peripheral artery disease. Paclitaxel has been successful in inhibiting neointimal hyperplasia, the main mechanism for in-stent restenosis. Technological advances have facilitated the development of paclitaxel-coated balloons, which show promise in early trials for femoropopliteal stenosis relative to uncoated balloons. For infrapopliteal stenoses, the data remain scant and conflicted. Therefore, large-scale randomized clinical trials with long-term follow-up evaluating safety and effectiveness between various strategies need to be performed to determine the optimal invasive management strategy for infrainguinal peripheral artery disease.
MeSH terms
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Angioplasty* / adverse effects
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Angioplasty* / instrumentation
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Angioplasty* / methods
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Antineoplastic Agents, Phytogenic / pharmacology
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Coated Materials, Biocompatible / pharmacology
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Constriction, Pathologic / diagnosis
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Constriction, Pathologic / etiology
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Constriction, Pathologic / physiopathology
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Constriction, Pathologic / prevention & control
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Drug-Eluting Stents
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Femoral Artery* / diagnostic imaging
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Femoral Artery* / physiopathology
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Femoral Artery* / surgery
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Humans
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Hyperplasia
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Long Term Adverse Effects* / diagnosis
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Long Term Adverse Effects* / etiology
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Long Term Adverse Effects* / physiopathology
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Long Term Adverse Effects* / prevention & control
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Neointima / pathology*
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Paclitaxel / pharmacology*
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Peripheral Arterial Disease* / diagnosis
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Peripheral Arterial Disease* / physiopathology
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Peripheral Arterial Disease* / surgery
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Popliteal Artery* / diagnostic imaging
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Popliteal Artery* / physiopathology
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Popliteal Artery* / surgery
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Vascular Patency
Substances
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Antineoplastic Agents, Phytogenic
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Coated Materials, Biocompatible
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Paclitaxel