Liver resection for perihilar cholangiocarcinoma - why left is sometimes right

HPB (Oxford). 2016 Jul;18(7):575-9. doi: 10.1016/j.hpb.2016.05.002. Epub 2016 May 26.

Abstract

Introduction: Left-sided liver resection (LLR) for perihilar cholangiocarcinoma (PHC) may require right hepatic artery (RHA) resection and reconstruction because of its intimate relationship with the biliary confluence. Consequently right-sided resections (RLR) are preferred for Bismuth-Corlette IIIb tumours, and resections avoided in Bismuth-Corlette IV tumours with left lobar atrophy when the RHA is involved by tumour.

Methods: A retrospective analysis of patients with PHC who presented between December 2009 and June 2015.

Results: Thirty-six patients underwent resection for PHC (23 LLR, 13 RLR). The number of Bismuth-Corlette IV patients undergoing LLR was significantly greater than those undergoing RLR (8/23 vs 0/13, p = 0.032). The need for arterial reconstruction (AR) was significantly greater during LLR than RLR (10/23 vs 0/13, p = 0.006). Postoperative liver dysfunction was greater after RLR (5/13 vs 0/23, p = 0.003), and hospital stay was shorter after LLR (10 vs 15 days, p = 0.013).

Conclusions: Safe AR increases the ability to perform potentially curative LLR for PHC. This improves the resectability rate for PHC, particularly for Bismuth-Corlette Type IV tumours. The larger liver remnant after LLR results in less postoperative liver dysfunction and shorter hospital stay without increased operating time, blood loss or morbidity.

MeSH terms

  • Adult
  • Aged
  • Bile Duct Neoplasms / pathology
  • Bile Duct Neoplasms / surgery*
  • Cholangiocarcinoma / pathology
  • Cholangiocarcinoma / surgery*
  • Female
  • Hepatectomy / adverse effects
  • Hepatectomy / methods*
  • Hepatic Artery / pathology
  • Hepatic Artery / surgery
  • Humans
  • Kaplan-Meier Estimate
  • Length of Stay
  • Liver Function Tests
  • Male
  • Middle Aged
  • Postoperative Complications / etiology
  • Postoperative Complications / physiopathology
  • Retrospective Studies
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Young Adult