Abstract
Mef2c Anterior Heart Field (AHF) enhancer is activated during embryonic heart development and it is expressed in multipotent cardiovascular progenitors (CVP) giving rise to endothelial and myocardial components of the outflow tract, right ventricle and ventricular septum. Here we have generated iPSC from transgenic Mef2c-AHF-Cre x Ai6(RCLZsGreen) mice. These iPSC will provide a novel tool to investigate the AHF-CVP and their cell progeny.
Copyright © 2016 Roslin Cells Ltd. Published by Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Differentiation
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Cellular Reprogramming
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Embryoid Bodies / cytology
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Embryoid Bodies / metabolism
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Fibroblasts / cytology*
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Genotype
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Induced Pluripotent Stem Cells / cytology*
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Induced Pluripotent Stem Cells / metabolism
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Karyotype
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MEF2 Transcription Factors / genetics
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Myocardium / cytology*
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Teratoma / metabolism
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Teratoma / pathology
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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MEF2 Transcription Factors
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Mef2c protein, mouse
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Transcription Factors