The role of variants from the innate immune system genes in tuberculosis and skin test response in a Native American population

Hum Immunol. 2016 Oct;77(10):981-984. doi: 10.1016/j.humimm.2016.06.017. Epub 2016 Jun 23.

Abstract

Native American populations show higher tuberculosis (TB) mortality and infectivity rates than non-Native populations. Variants in the innate immune system seem to have an important role on TB susceptibility. The role of some innate immune system variants in TB susceptibility and/or skin test response (PPD) were investigated in the Aché, a Native American population. Complement receptor 1 and toll like receptor 9 variants were associated with anergy to PPD and protection to TB, respectively. These findings demonstrate an important role of the innate immune system variants in TB susceptibility.

Keywords: Amerindians; CR1; Innate immunity; TLR9; Tuberculosis.

MeSH terms

  • Adult
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Immunity, Innate / genetics
  • Indians, South American*
  • Male
  • Middle Aged
  • Paraguay
  • Polymorphism, Single Nucleotide
  • Receptors, Complement / genetics
  • Toll-Like Receptor 9 / genetics*
  • Tuberculin Test
  • Tuberculosis, Pulmonary / genetics*
  • Young Adult

Substances

  • Receptors, Complement
  • TLR9 protein, human
  • Toll-Like Receptor 9