Direct Hydroxylation and Amination of Arenes via Deprotonative Cupration

J Am Chem Soc. 2016 Jul 27;138(29):9166-71. doi: 10.1021/jacs.6b03855. Epub 2016 Jul 14.

Abstract

Deprotonative directed ortho cupration of aromatic/heteroaromatic C-H bond and subsequent oxidation with t-BuOOH furnished functionalized phenols in high yields with high regio- and chemoselectivity. DFT calculations revealed that this hydroxylation reaction proceeds via a copper (I → III → I) redox mechanism. Application of this reaction to aromatic C-H amination using BnONH2 efficiently afforded the corresponding primary anilines. These reactions show broad scope and good functional group compatibility. Catalytic versions of these transformations are also demonstrated.

Publication types

  • Research Support, Non-U.S. Gov't