How can we address the controversies surrounding the use of NSAIDS in neurodegeneration?

Future Med Chem. 2016 Jul;8(11):1153-5. doi: 10.4155/fmc-2016-0084. Epub 2016 Jun 30.
No abstract available

Keywords: COX-1-10aa-PGIS; COX-2-10aa-mPGES-1; NSAIDs; PGE2; PGI2; cyclooxygenase; hybrid enzyme; neurodegeneration; neuroinflammation; nonsteroidal anti-inflammatory drugs.

Publication types

  • Editorial

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Arachidonic Acid / metabolism
  • Cyclooxygenase 1 / chemistry
  • Cyclooxygenase 1 / metabolism
  • Cyclooxygenase 2 / chemistry
  • Cyclooxygenase 2 / metabolism
  • Dinoprostone / metabolism
  • Epoprostenol / metabolism
  • Humans
  • Neurodegenerative Diseases / drug therapy*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Arachidonic Acid
  • Epoprostenol
  • Cyclooxygenase 1
  • Cyclooxygenase 2
  • Dinoprostone