Acute promyelocytic leukemia co-existing with JAK2 V617F positive myeloproliferative neoplasm: a case report

Aleksandra Mamorska-Dyga; Jingjing Wu; Pallavi Khattar; Faisal M H Ronny; Humayun Islam; Karen Seiter; Delong Liu

doi:10.21037/sci.2016.03.02

Acute promyelocytic leukemia co-existing with JAK2 V617F positive myeloproliferative neoplasm: a case report

Stem Cell Investig. 2016 Mar 24:3:8. doi: 10.21037/sci.2016.03.02. eCollection 2016.

Authors

Aleksandra Mamorska-Dyga¹, Jingjing Wu¹, Pallavi Khattar¹, Faisal M H Ronny¹, Humayun Islam¹, Karen Seiter¹, Delong Liu¹

Affiliation

¹ 1 Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA ; 2 Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China ; 3 Department of Pathology, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA.

Abstract

The V617F mutation of Janus-associated kinase 2 (JAK2) is commonly seen in myeloproliferative neoplasms (MPN). Transformation of JAK2 positive MPNs to acute leukemia has been reported. We here report a case of acute promyelocytic leukemia which was later confirmed to have a co-existing JAK2 V617F positive MPN. In addition, the patient was found to have FLT3-TKD mutation, which, together with PML/RARa, could play a role in the MPN transformation to APL.

Keywords: Acute myelogenous leukemia (APL); Janus-associated kinase 2 (JAK2); PML/RARa; myeloproliferative neoplasms (MPN).

Publication types

Case Reports