Abstract
New bisindole alkaloids, hyrtinadines C (1) and D (2), have been isolated from an Okinawan marine sponge Hyrtios sp. The structures of hyrtinadines C (1) and D (2) were elucidated based on analyses of the spectral data. Hyrtinadines C (1) and D (2) were the relatively rare alkaloids possessing a 3,4-fused azepinoindole skeleton. Hyrtinadines C (1) and D (2) showed antimicrobial activity.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology*
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Aspergillus niger / drug effects
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Bacillus subtilis / drug effects
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Candida albicans / drug effects
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Cryptococcus neoformans / drug effects
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Dose-Response Relationship, Drug
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Escherichia coli / drug effects
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification
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Indole Alkaloids / pharmacology*
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Microbial Sensitivity Tests
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Micrococcus luteus / drug effects
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Molecular Structure
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Porifera / chemistry*
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Staphylococcus aureus / drug effects
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Structure-Activity Relationship
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Trichophyton / drug effects
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Indole Alkaloids
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hyrtinadine C
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hyrtinadine D