Identification of a novel HLA-B null allele, HLA-B*41:45N, by HLA typing of two related Caucasoid individuals

HLA. 2016 Jul;88(1-2):50-1. doi: 10.1111/tan.12834. Epub 2016 Jul 4.

Abstract

The new HLA-B*41:45N allele differs from B*41:02 by insertion of 21 nucleotides in exon 2.

Keywords: B*41:45N; HLA-B; null allele; sequence-based typing.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Alleles*
  • Base Sequence
  • Exons*
  • Family
  • Female
  • Gene Expression
  • Genotype
  • HLA-B Antigens / genetics*
  • HLA-B Antigens / immunology
  • Hematopoietic Stem Cell Transplantation
  • Histocompatibility Testing
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / immunology
  • Leukemia, Myeloid, Acute / pathology
  • Leukemia, Myeloid, Acute / therapy
  • Middle Aged
  • Mutagenesis, Insertional*
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Tissue Donors*
  • White People

Substances

  • HLA-B Antigens
  • HLA-B*41 antigen