Outbreak of mortality in Russian (Acipenser gueldenstaedtii) and Siberian (Acipenser baerii) sturgeons associated with sturgeon nucleo-cytoplasmatic large DNA virus

Vet Microbiol. 2016 Aug 15:191:27-34. doi: 10.1016/j.vetmic.2016.05.012. Epub 2016 May 25.

Abstract

Diseased outbreaks with high mortality in farmed sturgeon are a limiting factor to the success of this emerging aquaculture sector in Europe. Thorough investigations of outbreaks can determine the aetiological agents, identify important pathological and epidemiological pathways of infections and pave the way for effective control strategies. A thorough investigation of a mortality outbreak in Russian (Acipenser gueldenstaedtii) and Siberian (Acipenser baerii) sturgeons in Italy, demonstrated the primary involvement of a sturgeon nucleo-cytoplasmic large DNA virus (NCLDV). While, the taxonomy classification of this new virus is still uncertain, its involvement in sturgeon mortality outbreaks in Europe is, for the first time, fully investigated and described. Furthermore, the coinfection of bacteria such as motile Aeromonas spp. and Acinetobacter spp. was reported. Genetic characterisation showed the close relationship between the European sturgeon NCLDV with North American sturgeon NCLDVs. Similarly to the latter, the European sturgeon NCLDV persists in survivors. Furthermore, a systemic distribution of the European sturgeon NCLDV was evident in diseased A. baerii and A. gueldenstaedtii and in recovered A. gueldenstaedtii. These epidemiological and pathological findings will help in the identification of effective control strategies for sturgeon NCLDV infection, which afflicts an important and emerging European aquaculture sector.

Keywords: Acinetobacter spp.; Acipenser baerii; Acipenser gueldenstaedtii; Mortality outbreak; Sturgeon nucleo-cytoplasmic large DNA virus.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Aquaculture
  • Capsid Proteins / chemistry
  • Capsid Proteins / genetics
  • DNA Virus Infections / epidemiology
  • DNA Virus Infections / mortality
  • DNA Virus Infections / veterinary*
  • DNA Virus Infections / virology
  • DNA Viruses / classification*
  • DNA Viruses / genetics
  • DNA Viruses / physiology
  • Disease Outbreaks*
  • Fish Diseases / epidemiology*
  • Fish Diseases / mortality*
  • Fish Diseases / prevention & control
  • Fish Diseases / virology
  • Fishes
  • Italy / epidemiology
  • Phylogeny
  • Russia / epidemiology

Substances

  • Capsid Proteins