FOXP3(+) CD4 T-cell maturity and responses to microbial stimulation alter with age and associate with early-life gut colonization

J Allergy Clin Immunol. 2016 Sep;138(3):905-908.e4. doi: 10.1016/j.jaci.2016.04.027. Epub 2016 May 30.

Authors

Sophia Björkander¹, Maria A Johansson², Lena Hell², Gintare Lasaviciute², Caroline Nilsson³, Ulrika Holmlund², Eva Sverremark-Ekström²

Affiliations

¹ Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden. Electronic address: [email protected].
² Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
³ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet and Sachs' Children's Hospital, Stockholm, Sweden.

PMID: 27378752
DOI: 10.1016/j.jaci.2016.04.027

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
CD4-Positive T-Lymphocytes / immunology*
Child
Child, Preschool
Cross-Sectional Studies
Female
Forkhead Transcription Factors / immunology*
Gastrointestinal Microbiome / immunology*
Humans
Interleukin-10 / immunology
Interleukin-2 Receptor alpha Subunit / immunology
Interleukin-7 Receptor alpha Subunit / immunology
Male
Middle Aged
Prospective Studies
T-Lymphocytes, Regulatory / immunology*
Young Adult

Substances

FOXP3 protein, human
Forkhead Transcription Factors
Interleukin-2 Receptor alpha Subunit
Interleukin-7 Receptor alpha Subunit
Interleukin-10