Diffusion-weighted imaging reflects variable cellularity and stromal density present in breast fibroadenomas

Sana Parsian; Nadia V Giannakopoulos; Habib Rahbar; Mara H Rendi; Xiaoyu Chai; Savannah C Partridge

doi:10.1016/j.clinimag.2016.06.002

Diffusion-weighted imaging reflects variable cellularity and stromal density present in breast fibroadenomas

Clin Imaging. 2016 Sep-Oct;40(5):1047-54. doi: 10.1016/j.clinimag.2016.06.002. Epub 2016 Jun 13.

Authors

Sana Parsian¹, Nadia V Giannakopoulos², Habib Rahbar³, Mara H Rendi⁴, Xiaoyu Chai⁵, Savannah C Partridge⁶

Affiliations

¹ Department of Radiology, Seattle Cancer Care Alliance, University of Washington School of Medicine, 825 Eastlake Ave. E., G3-200, Seattle, WA 98109-1023, USA. Electronic address: [email protected].
² Department of Anatomic Pathology, University of Washington School of Medicine, 1959 NE Pacific St., Box 356100, Seattle, WA 98195, USA. Electronic address: [email protected].
³ Department of Radiology, Seattle Cancer Care Alliance, University of Washington School of Medicine, 825 Eastlake Ave. E., G3-200, Seattle, WA 98109-1023, USA. Electronic address: [email protected].
⁴ Department of Anatomic Pathology, University of Washington School of Medicine, 1959 NE Pacific St., Box 356100, Seattle, WA 98195, USA. Electronic address: [email protected].
⁵ Department of Biostatistics & Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M2-B500, Seattle, WA 98109, USA. Electronic address: [email protected].
⁶ Department of Radiology, Seattle Cancer Care Alliance, University of Washington School of Medicine, 825 Eastlake Ave. E., G3-200, Seattle, WA 98109-1023, USA. Electronic address: [email protected].

Abstract

Objective: To determine the underlying histopathologic features influencing apparent diffusion coefficient (ADC) values of breast fibroadenomas.

Materials and methods: Biopsy-proven fibroadenomas (n=26) initially identified as suspicious on breast magnetic resonance imaging (MRI) were retrospectively evaluated. Histopathologic assessments of lesion cellularity and stromal type were compared with ADC measures on diffusion-weighted MRI.

Results: Presence of epithelial hyperplasia (increased cellularity) and dense collagenous stroma were both significantly associated with lower lesion ADC values (P=.02 and .004, respectively).

Conclusion: Variations in epithelial cellularity and stromal type influence breast lesion ADC values and may explain the wide range of ADC measures observed in benign fibroadenomas.

Keywords: Apparent diffusion coefficient (ADC); Cellularity; Diffusion-weighted imaging (DWI); Fibroadenomas; Stroma.

MeSH terms

Adult
Aged
Biopsy
Breast / diagnostic imaging*
Breast / pathology
Breast Density*
Breast Neoplasms / diagnostic imaging*
Breast Neoplasms / pathology
Diffusion Magnetic Resonance Imaging*
False Positive Reactions
Female
Fibroadenoma / diagnostic imaging*
Fibroadenoma / pathology
Humans
Middle Aged
Retrospective Studies

Abstract

MeSH terms

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