Defining Obesity Using a Biological End Point in Sri Lankan Children

Indian J Pediatr. 2017 Feb;84(2):117-123. doi: 10.1007/s12098-016-2191-2. Epub 2016 Jul 7.

Abstract

Objective: To identify the percentage of body fat mass (FM) that would define obesity among Sri Lankan children.

Methods: A cross-sectional study was conducted among 5-15 y old children in the district of Colombo. FM was assessed using Bio Impedance Assay (BIA). After a 12 h overnight fast, blood was drawn for fasting blood glucose (FBS) and lipid profile. Oral-glucose-tolerance test (OGTT) was done along with 2 h random blood sugar (RBS). Metabolic syndrome (MetS) was diagnosed by a high waist circumference (WC) with ≥2 metabolic derangements [FBS/RBS, high density lipoprotein-cholesterol (HDL-C), triglyceride, and systolic and diastolic blood pressure (SBP/DBP)]. Receiver-Operator Characteristics (ROCs) were drawn to determine the best %FM that predicted MetS.

Results: Nine hundred twenty children were studied (547 boys). Fifteen (1.6 %) had MetS. Ninety five (10.3 %) had two and 16(1.7 %) had ≥3 metabolic derangements. MetS in boys was associated with %FM of 28.6 (sensitivity 1.000; specificity 0.870) and in girls 33.7 (sensitivity 0.875; specificity 0.808).

Conclusions: FM associated with adverse health outcomes in this population is comparable to other available data. A %FM of 28.6 % for boys and 33.7 % for girls would be acceptable cutoff limits.

Keywords: Fat mass; Fat percentage; Metabolic derangements; Obesity diagnosis; Sri Lankan children.

MeSH terms

  • Adolescent
  • Anthropometry / methods*
  • Biomarkers / analysis
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Metabolic Syndrome / epidemiology
  • Pediatric Obesity / epidemiology*
  • Sri Lanka / epidemiology

Substances

  • Biomarkers