A paediatric case of successful non-myeloablative bone marrow transplantation after azacitidine therapy for non-Down syndrome acute megakaryoblastic leukaemia with monosomy 7

Pediatr Transplant. 2016 Sep;20(6):868-70. doi: 10.1111/petr.12739. Epub 2016 Jul 6.

Abstract

We report a patient with non-Down syndrome AML, also known as AMKL, with monosomy 7, who was also obese and had a hearing impairment and mental retardation. Non-myeloablative bone marrow transplantation was performed successfully after the patient received less aggressive azacitidine treatment, without the usual intensive induction chemotherapy regimen for AML.

Keywords: acute megakaryoblastic leukaemia; azacitidine; monosomy 7.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antimetabolites, Antineoplastic / therapeutic use*
  • Azacitidine / therapeutic use*
  • Bone Marrow Transplantation / methods*
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 7
  • Combined Modality Therapy
  • Humans
  • Leukemia, Megakaryoblastic, Acute / genetics
  • Leukemia, Megakaryoblastic, Acute / therapy*
  • Male

Substances

  • Antimetabolites, Antineoplastic
  • Azacitidine

Supplementary concepts

  • Chromosome 7, monosomy