A Protocol for NMR Analysis of the Enantiomeric Excess of Chiral Diols Using an Achiral Diboronic Acid Template

J Org Chem. 2016 Aug 5;81(15):6795-9. doi: 10.1021/acs.joc.6b01005. Epub 2016 Jul 22.

Abstract

A practically simple derivatization protocol for determining the enantiopurity of chiral diols by (1)H NMR spectroscopic analysis is described. Diols were treated with 0.5 equiv of 1,3-phenyldiboronic acid to afford mixtures of diastereomeric boronate esters whose homochiral/heterochiral ratios are an accurate reflection of the diol's enantiopurity.

Publication types

  • Research Support, Non-U.S. Gov't