Impact of telomere length on the outcome of allogeneic stem cell transplantation for poor-risk chronic lymphocytic leukaemia: results from the GCLLSG CLL3X trial

Br J Haematol. 2017 Oct;179(2):342-346. doi: 10.1111/bjh.14219. Epub 2016 Jul 8.

Authors

Annika Scheffold¹, Billy Michael Chelliah Jebaraj¹, Sonia Jaramillo¹, Eugen Tausch¹, Daniela Steinbrecher¹, Michael Hahn², Sebastian Böttcher³, Matthias Ritgen³, Donald Bunjes¹, Matthias Zeis⁴, Michael Stadler⁵, Lutz Uharek⁶, Christoph Scheid⁷, Ute Hegenbart², Michael Hallek⁷, Michael Kneba³, Norbert Schmitz⁴, Hartmut Döhner¹, Peter Dreger², Stephan Stilgenbauer¹

Affiliations

¹ Department of Internal Medicine III, University of Ulm, Ulm, Germany.
² Department of Medicine V, University of Heidelberg, Heidelberg, Germany.
³ Department of Medicine II, University Medical Centre Schleswig-Holstein, Kiel, Germany.
⁴ Department of Haematology and Stem Cell Transplantation, Asklepios Klinik St. Georg, Hamburg, Germany.
⁵ Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
⁶ Department of Medicine for Haematology, Oncology and Tumour Immunology, Charité Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, Germany.
⁷ Department of Medicine I, Centre for Integrated Oncology Cologne Bonn, University of Cologne, Cologne, Germany.

PMID: 27391907
DOI: 10.1111/bjh.14219

No abstract available

Keywords: Allogeneic stem cell transplantation; Chronic lymphocytic leukaemia; Telomere length.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Aberrations
Clinical Trials, Phase II as Topic
Follow-Up Studies
Hematopoietic Stem Cell Transplantation / methods
Humans
Immunoglobulin Heavy Chains / genetics
Immunoglobulin Variable Region / genetics
In Situ Hybridization, Fluorescence
Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Leukemia, Lymphocytic, Chronic, B-Cell / mortality*
Leukemia, Lymphocytic, Chronic, B-Cell / therapy
Multicenter Studies as Topic
Mutation
Prognosis
Telomere / genetics*
Telomere Homeostasis / genetics*
Telomere Shortening
Transplantation, Homologous
Treatment Outcome

Substances

Immunoglobulin Heavy Chains
Immunoglobulin Variable Region