Our Mothers' Antibodies as Guardians of our Commensals

Stephanie C Ganal-Vonarburg; Andrew J Macpherson

doi:10.1016/j.molmed.2016.06.010

Our Mothers' Antibodies as Guardians of our Commensals

Trends Mol Med. 2016 Sep;22(9):739-741. doi: 10.1016/j.molmed.2016.06.010. Epub 2016 Jul 19.

Authors

Stephanie C Ganal-Vonarburg¹, Andrew J Macpherson²

Affiliations

¹ Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin, Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland. Electronic address: [email protected].
² Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin, Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland. Electronic address: [email protected].

PMID: 27396513
DOI: 10.1016/j.molmed.2016.06.010

Abstract

Mucosal secretory IgA protects the mammalian body from invasion of commensal bacteria colonizing the intestine. A recent murine study in Cell shows that commensal-specific antibodies of the IgG isotype are also present in the serum and that maternal commensal-specific IgA and IgG are crucial for maintaining host-microbe mutualism in the offspring.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Animals, Newborn
Female
Immunity
Immunoglobulin A, Secretory / immunology*
Immunoglobulin G / blood
Immunoglobulin G / immunology*
Intestines / immunology
Intestines / microbiology*
Lactation
Mice
Milk / immunology
Pregnancy
Symbiosis

Substances

Immunoglobulin A, Secretory
Immunoglobulin G