Leukemia in Patients with Klinefelter Syndrome: A Report of Two Cases

M Bchir; W Ayed; H Ben Neji; O Kilani; S Kefi; M Zarrouk; H Guermani; S Hentati; A Amouri; B Meddeb

doi:10.1007/s12288-015-0590-6

Leukemia in Patients with Klinefelter Syndrome: A Report of Two Cases

Indian J Hematol Blood Transfus. 2016 Jun;32(Suppl 1):66-8. doi: 10.1007/s12288-015-0590-6. Epub 2015 Sep 2.

Authors

M Bchir¹, W Ayed², H Ben Neji¹, O Kilani², S Kefi¹, M Zarrouk¹, H Guermani², S Hentati², A Amouri², B Meddeb¹

Affiliations

¹ Department of Hematology, Aziza Othmana University Hospital, Place du gouvernement, la Kasbbah, 1008 Tunis, Tunisia.
² Laboratory of Histology and Cytogenetics, Department of Histology and Cytogenetics, Faculty of Medicine of Tunis, Institut Pasteur de Tunis, El Manar Tunis University, 13, Place Pasteur, BP74, 1002 Tunis, Tunisia.

Abstract

Klinefelter syndrome (KS) is a chromosome abnormality characterized by a 47, XXY karyotype associated with hypogonadism and infertility. We present two cases of leukemia in patients with KS. The first patient presented with acute promyelocytic leukemia. He relapsed after the end of treatment. The second patient was diagnosed with chronic myeloid leukemia. Treatment with imatinib failed and the patient presented with myeloid blast crisis.

Keywords: Acute promyelocytic leukemia; Chronic myelogenous leukemia; Karyotype; Klinefelter syndrome.