Pink Light on Mitochondria in Autoimmunity and Parkinson Disease

Adriana R Mantegazza; Michael S Marks

doi:10.1016/j.cmet.2016.06.022

Pink Light on Mitochondria in Autoimmunity and Parkinson Disease

Cell Metab. 2016 Jul 12;24(1):11-2. doi: 10.1016/j.cmet.2016.06.022.

Authors

Adriana R Mantegazza¹, Michael S Marks²

Affiliations

¹ Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: [email protected].

Abstract

Mitochondrial dysfunction and T cell autoimmunity have been independently implicated in Parkinson disease pathogenesis. In a recent publication in Cell, Matheoud et al. (2016) link them by describing a new mechanism, activated in familial forms of Parkinson disease, in which mitochondrial proteins are processed for recognition by CD8+ T cells.

Publication types

Comment

MeSH terms

Autoimmunity*
Humans
Mitochondria
Mitochondrial Proteins
Parkinson Disease*

Substances

Mitochondrial Proteins

Grants and funding

R01 HL121323/HL/NHLBI NIH HHS/United States