RETRACTED: Physcion 8-O-β-glucopyranoside induces apoptosis, suppresses invasion and inhibits epithelial to mesenchymal transition of hepatocellular carcinoma HepG2 cells

Biomed Pharmacother. 2016 Oct:83:372-380. doi: 10.1016/j.biopha.2016.06.045. Epub 2016 Jul 14.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Panels from Figure 4A appear similar to panels from Figure 1 of the article previously published by Z. Ding, F. Xu, J. Tang, G. Li, P. Jiang, Z. Tang and H. Wu in Neoplasma 63(3) (2016) 351–361 http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=4703&category_id=128&option=com_virtuemart&vmcchk=1&Itemid=1. One of the conditions of submission of a paper for publication is that authors declare explicitly that the paper has not been previously published and is not under consideration for publication elsewhere. Re-use of any data should be appropriately cited. As such this article represents a misuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

Keywords: DNMT1; Physcion 8-O-β-glucopyranoside; ROS; Sp1.

Publication types

  • Retracted Publication

MeSH terms

  • Adenylate Kinase / metabolism
  • Apoptosis / drug effects*
  • Carcinoma, Hepatocellular / pathology*
  • Caspases / metabolism
  • Cell Cycle Checkpoints / drug effects
  • Cell Movement / drug effects
  • Cell Proliferation / drug effects
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA (Cytosine-5-)-Methyltransferases / metabolism
  • Down-Regulation / drug effects
  • Emodin / analogs & derivatives*
  • Emodin / pharmacology
  • Epithelial-Mesenchymal Transition / drug effects*
  • Glucosides / pharmacology*
  • Hep G2 Cells
  • Humans
  • Liver Neoplasms / pathology*
  • Neoplasm Invasiveness
  • Reactive Oxygen Species / metabolism
  • Signal Transduction / drug effects
  • Sp1 Transcription Factor / metabolism

Substances

  • Glucosides
  • Reactive Oxygen Species
  • Sp1 Transcription Factor
  • physcion 8-O-glucopyranoside
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA (Cytosine-5-)-Methyltransferases
  • DNMT1 protein, human
  • Adenylate Kinase
  • Caspases
  • physcione
  • Emodin