Abstract
The MEGA-PRESS pulse sequence was used for determination of overlapping signals in the (1)H-MRS spectra of the human brain. For the first time, the balance of GABA glutamate/glutamine concentrations was estimated quantitatively in the human brain of patients with ultra-high risk of schizophrenia. It was found that GABA concentration and GABA/GLX ratios were significantly reduced in the left frontal lobe of UHR subjects.
MeSH terms
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Adolescent
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Adult
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Creatine / metabolism
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Frontal Lobe / diagnostic imaging
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Frontal Lobe / metabolism*
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Functional Laterality
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Glutamic Acid / metabolism*
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Glutamine / metabolism*
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Humans
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Male
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Prodromal Symptoms
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Proton Magnetic Resonance Spectroscopy / methods*
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Risk
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Schizophrenia / diagnostic imaging
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Schizophrenia / metabolism*
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Young Adult
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gamma-Aminobutyric Acid / metabolism*
Substances
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Glutamine
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Glutamic Acid
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gamma-Aminobutyric Acid
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Creatine