Parotid Gland Biopsy, the Alternative Way to Diagnose Sjögren Syndrome

Fred K L Spijkervet; Erlin Haacke; Frans G M Kroese; Hendrika Bootsma; Arjan Vissink

doi:10.1016/j.rdc.2016.03.007

Parotid Gland Biopsy, the Alternative Way to Diagnose Sjögren Syndrome

Rheum Dis Clin North Am. 2016 Aug;42(3):485-99. doi: 10.1016/j.rdc.2016.03.007. Epub 2016 Jun 21.

Authors

Fred K L Spijkervet¹, Erlin Haacke², Frans G M Kroese³, Hendrika Bootsma³, Arjan Vissink⁴

Affiliations

¹ Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: [email protected].
² Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
³ Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
⁴ Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.

PMID: 27431350
DOI: 10.1016/j.rdc.2016.03.007

Abstract

Salivary gland biopsy is a technique broadly applied for the diagnosis of Sjögren syndrome (SS), lymphoma in SS, and connective tissue disorders (sarcoidosis, amyloidosis). In SS characteristic histology findings are found, including lymphocytic infiltration surrounding the excretory ducts in combination with destruction of acinar tissue. In this article the main techniques are described for taking labial and parotid salivary gland biopsies with respect to their advantages, postoperative complications, and usefulness for diagnostic procedures, monitoring disease progression, and evaluation of treatment.

Keywords: Biopsy; Diagnostics; Labial gland; Parotid gland; Salivary gland; Sjögren syndrome.

Publication types

Review

MeSH terms

Biopsy
Humans
Lip
Lymphoma, B-Cell / diagnosis
Lymphoma, B-Cell / pathology
Lymphoma, B-Cell, Marginal Zone / diagnosis
Lymphoma, B-Cell, Marginal Zone / pathology*
Parotid Gland / pathology*
Parotid Neoplasms / diagnosis
Parotid Neoplasms / pathology*
Salivary Glands, Minor / pathology*
Sensitivity and Specificity
Sjogren's Syndrome / diagnosis
Sjogren's Syndrome / pathology*