Mass cytometry: blessed with the curse of dimensionality

Nat Immunol. 2016 Jul 19;17(8):890-5. doi: 10.1038/ni.3485.

Abstract

Immunologists are being compelled to develop new high-dimensional perspectives of cellular heterogeneity and to determine which applications best exploit the power of mass cytometry and associated multiplex approaches.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Animals
  • Antibodies, Monoclonal / immunology
  • Combinatorial Chemistry Techniques
  • Cytological Techniques / instrumentation
  • Cytological Techniques / methods*
  • Flow Cytometry
  • Humans
  • Immunophenotyping / methods
  • Machine Learning
  • Macromolecular Substances / analysis
  • Mathematics
  • Myeloid Cells / immunology
  • Sensitivity and Specificity
  • Single-Cell Analysis / methods
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
  • T-Cell Antigen Receptor Specificity
  • T-Lymphocyte Subsets / immunology

Substances

  • Antibodies, Monoclonal
  • Macromolecular Substances