Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2

Leukemia. 2016 Nov;30(11):2254-2258. doi: 10.1038/leu.2016.196. Epub 2016 Jul 20.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Chromosomes, Human, Pair 11*
  • DNA (Cytosine-5-)-Methyltransferases / genetics*
  • DNA Methyltransferase 3A
  • Female
  • Histone-Lysine N-Methyltransferase / genetics*
  • Humans
  • Isocitrate Dehydrogenase / genetics*
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Middle Aged
  • Mutation*
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Splicing Factor U2AF / genetics*
  • Trisomy*
  • fms-Like Tyrosine Kinase 3 / genetics*

Substances

  • DNMT3A protein, human
  • KMT2A protein, human
  • Splicing Factor U2AF
  • U2AF1 protein, human
  • Myeloid-Lymphoid Leukemia Protein
  • IDH2 protein, human
  • Isocitrate Dehydrogenase
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methyltransferase 3A
  • Histone-Lysine N-Methyltransferase
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3