Abstract
Bioprosthetic valve thrombosis is an uncommon complication. We report two young women with prior uncomplicated percutaneous pulmonary valve replacement (Melody® , Medtronic, Inc. Minneapolis, MN) who later developed symptomatic pulmonary emboli and pulmonary valve dysfunction without evidence of infection. Thrombophilia risk factors included oral contraceptive use and mild thrombophilia. Both experienced recovery of valve function following anticoagulation. Acute changes in Melody® valve function should prompt a thorough investigation for and treatment of potential thrombotic causes. © 2016 Wiley Periodicals, Inc.
Keywords:
bioprosthetic valve thrombosis; factor V Leiden; pulmonary embolism; thrombophilia; thrombosis.
© 2016 Wiley Periodicals, Inc.
Publication types
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Case Reports
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Video-Audio Media
MeSH terms
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Anticoagulants / therapeutic use
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Bioprosthesis*
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Cardiac Catheterization / adverse effects*
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Cardiac Catheterization / instrumentation*
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Cardiac Catheterization / methods
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Echocardiography, Doppler
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Female
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Heart Valve Prosthesis Implantation / adverse effects*
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Heart Valve Prosthesis Implantation / instrumentation*
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Heart Valve Prosthesis Implantation / methods
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Heart Valve Prosthesis*
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Hemodynamics
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Humans
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Prosthesis Design
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Pulmonary Embolism / etiology
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Pulmonary Valve Stenosis / diagnostic imaging
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Pulmonary Valve Stenosis / physiopathology
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Pulmonary Valve Stenosis / therapy*
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Pulmonary Valve* / diagnostic imaging
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Pulmonary Valve* / physiopathology
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Recovery of Function
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Thrombosis / diagnostic imaging
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Thrombosis / drug therapy
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Thrombosis / etiology*
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Thrombosis / physiopathology
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Treatment Outcome
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Young Adult