Role of functional imaging in treatment plan optimization of stereotactic body radiation therapy for liver cancer

Tumori. 2016 Oct 13;102(5):e21-e24. doi: 10.5301/tj.5000523.

Abstract

We report the first known instance of the clinical use of 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) for the optimization of radiotherapy treatment planning and for the follow-up of acute toxicity in a patient undergoing stereotactic body radiation therapy for hepatocellular carcinoma. In our experience, HBS allowed the identification and the sparing of more functioning liver areas, thus potentially reducing the risk of radiation-induced liver toxicity.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Aniline Compounds
  • Carcinoma, Hepatocellular / diagnostic imaging*
  • Carcinoma, Hepatocellular / radiotherapy*
  • Glycine
  • Humans
  • Imino Acids
  • Liver Function Tests
  • Liver Neoplasms / diagnostic imaging*
  • Liver Neoplasms / radiotherapy*
  • Magnetic Resonance Imaging
  • Male
  • Organotechnetium Compounds
  • Radionuclide Imaging
  • Radiosurgery* / adverse effects
  • Radiosurgery* / methods
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Aniline Compounds
  • Imino Acids
  • Organotechnetium Compounds
  • technetium Tc 99m mebrofenin
  • Glycine