Estimation of vessel diameter and blood flow dynamics from laser speckle images

Dmitry D Postnov; Valery V Tuchin; Olga Sosnovtseva

doi:10.1364/BOE.7.002759

Estimation of vessel diameter and blood flow dynamics from laser speckle images

Biomed Opt Express. 2016 Jun 22;7(7):2759-68. doi: 10.1364/BOE.7.002759. eCollection 2016 Jul 1.

Authors

Dmitry D Postnov¹, Valery V Tuchin², Olga Sosnovtseva¹

Affiliations

¹ Department of Biomedical Sciences, Copenhagen University, Blegdamsvej 3, 2200 Copenhagen N, Denmark.
² Research-Educational Institute of Optics and Biophotonics, Saratov National Research State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia; Institute of Precision Mechanics and Control RAS, Rabochaya str. 24, 410028 Saratov, Russia; Interdisciplinary Laboratory of Biophotonics, Tomsk National Research State University, 634050 Tomsk, Russia.

Abstract

Laser speckle imaging is a rapidly developing method to study changes of blood velocity in the vascular networks. However, to assess blood flow and vascular responses it is crucial to measure vessel diameter in addition to blood velocity dynamics. We suggest an algorithm that allows for dynamical masking of a vessel position and measurements of it's diameter from laser speckle images. This approach demonstrates high reliability and stability.

Keywords: (120.6150) Speckle imaging; (170.1470) Blood or tissue constituent monitoring; (170.5380) Physiology.