Lung Cancer Screening with Chest Computed Tomography in People Living with HIV: A Review by the Multidisciplinary CANCERVIH Working Group

Alain Makinson; Vincent Le Moing; Jacques Reynes; Tristan Ferry; Armelle Lavole; Isabelle Poizot-Martin; Jean-Louis Pujol; Jean-Philippe Spano; Bernard Milleron

doi:10.1016/j.jtho.2016.06.026

Lung Cancer Screening with Chest Computed Tomography in People Living with HIV: A Review by the Multidisciplinary CANCERVIH Working Group

J Thorac Oncol. 2016 Oct;11(10):1644-52. doi: 10.1016/j.jtho.2016.06.026. Epub 2016 Jul 20.

Authors

Alain Makinson¹, Vincent Le Moing², Jacques Reynes², Tristan Ferry³, Armelle Lavole⁴, Isabelle Poizot-Martin⁵, Jean-Louis Pujol⁶, Jean-Philippe Spano⁷, Bernard Milleron⁸

Affiliations

¹ Department of Infectious and Tropical Diseases, U1175-National Institute of Health and Medical Research/Mixt International Department 233, Development Research Institute, University Montpellier, Montpellier, France. Electronic address: [email protected].
² Department of Infectious and Tropical Diseases, U1175-National Institute of Health and Medical Research/Mixt International Department 233, Development Research Institute, University Montpellier, Montpellier, France.
³ Infectious and Tropical Disease Unit, University Hospital de la Croix Rousse, Lyon, France.
⁴ Department of Pneumology and Reanimation, Hôpital Tenon, Public Assistance-Parisian Hospitals, and Faculté de Médecine Pierre and Marie Curie, University Paris VI, Paris, France.
⁵ Clinical Immunohaematology Service, University Aix-Marseille, Public Assistance-Hospitals of Marseille Sainte-Marguerite, National Institute of Health and Medical Research, U912 (Economical and Social Sciences of Health and Treatment of Medical Information), Marseille, France.
⁶ Thoracic Oncology Unit, University Hospital Montpellier, Montpellier, French Cooperative Thoracic Intergroup, Paris, France.
⁷ Department of Medical Oncology, Groupe hospitalier Pitié-Salpêtrière-Charles Foix, Public Assistance-Parisian Hospitals, National Institute of Health and Medical Research, Mixt Research Department_S 1136, Institute Pierre Louis Epidemiology and of Public Health, Sorbonne University, University Pierre Marie Curie University Paris 06, Paris, France.
⁸ Respiratory Disease Department, Tenon Hospital APHP, Paris VI University, French Cooperative Thoracic Intergroup, Paris, France.

PMID: 27449803
DOI: 10.1016/j.jtho.2016.06.026

Abstract

A shift in mortality and morbidity has been observed in people living with human immunodeficiency virus (PLWHIV) from acquired immunodeficiency syndrome (AIDS) to non-AIDS diseases. Lung cancer has the highest incidence rates among all the non-AIDS-defining malignancies and is associated with mortality rates that exceed those of other cancers. Strategies to increase lung cancer survival in PLWHIV are needed. Lung cancer screening with chest LDCT has been shown to be efficient in the general population at risk. The objective of this review is to discuss lung cancer screening with chest computed tomography in PLWHIV. Lung cancer screening in PLWHIV is feasible. Whether PLWHIV could benefit from an age threshold for screening that is earlier than the minimum age of 55 years usually required in the general population still needs further investigation. Studies evaluating smoking cessation programs and how they could be articulated with lung cancer screening programs are also needed in PLWHIV.

Keywords: Computed tomography; HIV; Lung cancer; Screening; Smoking.

Publication types

Review

MeSH terms

Aged
HIV Infections / diagnostic imaging*
Humans
Lung Neoplasms / diagnostic imaging*
Lung Neoplasms / pathology
Mass Screening / methods*
Middle Aged
Thorax / diagnostic imaging*
Tomography, X-Ray Computed / methods*