Sclerosing Angiomatoid Nodular Transformation of the spleen, focal nodular hyperplasia and hemangioma of the liver: A tale of three lesions

Barbara Cafferata; Marco Pizzi; Francesco D'Amico; Claudia Mescoli; Rita Alaggio

doi:10.1016/j.prp.2016.07.003

Sclerosing Angiomatoid Nodular Transformation of the spleen, focal nodular hyperplasia and hemangioma of the liver: A tale of three lesions

Pathol Res Pract. 2016 Sep;212(9):855-8. doi: 10.1016/j.prp.2016.07.003. Epub 2016 Jul 5.

Authors

Barbara Cafferata¹, Marco Pizzi², Francesco D'Amico³, Claudia Mescoli¹, Rita Alaggio¹

Affiliations

¹ General Pathology & Cytopathology Unit, Department of Medicine-DIMED, University of Padova, Padova, Italy.
² General Pathology & Cytopathology Unit, Department of Medicine-DIMED, University of Padova, Padova, Italy. Electronic address: [email protected].
³ Hepatobiliary Surgery and Liver Transplantation Unit, University of Padova, Padova, Italy.

PMID: 27450658
DOI: 10.1016/j.prp.2016.07.003

Abstract

Sclerosing Angiomatoid Nodular Transformation (SANT) of the spleen is a benign vascular lesion with peculiar histological features. The pathogenesis of SANT is still largely unknown and variable etiologies have been proposed, including autoimmune, inflammatory, and/or vascular disorders. The present report describes a unique case of splenic SANT, associated with focal nodular hyperplasia and a sclerosing hemangioma of the liver. The clinic-pathological features of such an unusual case are thoroughly illustrated. Its possible pathogenic mechanisms are also briefly addressed.

Keywords: Focal nodular hyperplasia; Hemangioma; SANT; Sclerosing Angiomatoid Nodular Transformation; Spleen.

Publication types

Case Reports

MeSH terms

Focal Nodular Hyperplasia / pathology*
Hemangioma / pathology*
Humans
Liver / pathology*
Liver Neoplasms / pathology*
Male
Middle Aged
Sclerosis / pathology
Spleen / pathology*