Factors predicting successful discontinuation of continuous renal replacement therapy

S Katayama; S Uchino; M Uji; T Ohnuma; Y Namba; H Kawarazaki; N Toki; K Takeda; H Yasuda; J Izawa; N Tokuhira; I Nagata; Japanese Society of Education for Physicians and Trainees in Intensive Care (JSEPTIC) Clinical Trial Group

doi:10.1177/0310057X1604400401

Factors predicting successful discontinuation of continuous renal replacement therapy

Anaesth Intensive Care. 2016 Jul;44(4):453-7. doi: 10.1177/0310057X1604400401.

Affiliations

¹ MD, Intensive Care, Tokyo Women's Medical University, Department of Emergency Medicine, Asahi General Hospital, Chiba, Japan.
² MD, Intensive Care Unit, Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan.
³ MD, Intensive Care Unit, Osaka University Hospital, Osaka, Japan.
⁴ MD, Intensive Care Unit, Department of Anesthesiology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
⁵ MD, Department of Emergency and Critical Care, Showa University Fujigaoka Hospital, Kanagawa, Japan.
⁶ MD, Department of Nephrology and Hypertension, St. Marianna University School of Medicine, Kanagawa, Japan.
⁷ MD, Department of Internal Medicine, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.
⁸ MD, Division of Intensive Care Medicine, Hyogo College of Medicine, Hyogo, Japan.
⁹ MD, Intensive Care Unit, Department of Emergency and Critical Care Medicine, Japanese Red Cross Musashino Hospital, Tokyo, Japan.
¹⁰ MD, Division of Intensive Care, University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan.
¹¹ MD, Department of Emergency, Kanto Rosai Hospital, Kanagawa, Japan.

PMID: 27456174
DOI: 10.1177/0310057X1604400401

Abstract

This multicentre, retrospective observational study was conducted from January 2010 to December 2010 to determine the optimal time for discontinuing continuous renal replacement therapy (CRRT) by evaluating factors predictive of successful discontinuation in patients with acute kidney injury. Analysis was performed for patients after CRRT was discontinued because of renal function recovery. Patients were divided into two groups according to the success or failure of CRRT discontinuation. In multivariate logistic regression analysis, urine output at discontinuation, creatinine level and CRRT duration were found to be significant variables (area under the receiver operating characteristic curve for urine output, 0.814). In conclusion, we found that higher urine output, lower creatinine and shorter CRRT duration were significant factors to predict successful discontinuation of CRRT.

Keywords: acute kidney injury; continuous renal replacement therapy; creatinine level; urine output.

Publication types

Multicenter Study
Observational Study

MeSH terms

Acute Kidney Injury / therapy*
Aged
Creatinine / blood
Female
Humans
Logistic Models
Male
Middle Aged
Renal Replacement Therapy*
Retrospective Studies
Time Factors

Substances

Creatinine