Abstract
Chrysin-β-D-galactopyranoside was efficiently synthesized, evaluated for its inhibitory activities against H22 cell lines compared with chrysin, the scavenging of hydroxyl radical, DPPH radical and superoxide anion, inhibitory effect against bacteria and fungi. The structures of all compounds were fully characterized by spectroscopic data (NMR, MS). The anti-tumor, antioxidant and antimicrobial activities of chrysin-β-D-galactopyranoside were proved to be enhanced significantly compared with chrysin.
Keywords:
Antimicrobial activity; Antioxidant activity; Antitumor activity; Chrysin; Derivative; Glycosylation.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Antioxidants / chemical synthesis*
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Antioxidants / pharmacology
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Cell Line, Tumor
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical / methods
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Flavonoids / chemical synthesis*
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Flavonoids / pharmacology
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Free Radical Scavengers / chemical synthesis*
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Free Radical Scavengers / pharmacology
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Galactose / chemical synthesis*
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Galactose / pharmacology
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Humans
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Penicillium / drug effects
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Penicillium / physiology
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Antioxidants
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Flavonoids
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Free Radical Scavengers
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chrysin
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Galactose