Blood Transfusion Induced Opportunistic Adult T Cell Leukaemia/Lymphoma after Hodgkin's Disease

N P Williams; H Tsuda; K Yamaguchi; M Takeya; T Watanabe; T Ishii; I Hamaguchi; J Tsuruta; Y Ishimaru; K Takatsuki

doi:10.3109/10428199109067640

Blood Transfusion Induced Opportunistic Adult T Cell Leukaemia/Lymphoma after Hodgkin's Disease

Leuk Lymphoma. 1991;5(5-6):435-9. doi: 10.3109/10428199109067640.

Authors

N P Williams¹, H Tsuda¹, K Yamaguchi¹, M Takeya², T Watanabe³, T Ishii¹, I Hamaguchi¹, J Tsuruta⁴, Y Ishimaru⁴, K Takatsuki¹

Affiliations

¹ a Second Department of Internal Medicine, Kumamoto University Medical School, Honjo, 1-1-1, Kumamoto.
² b Second Department of Pathology, Kumamoto University Medical School, Honjo, 1-1-1, Kumamoto.
³ d Department of Pathology, The Institute of Medical Science, The University of Tokyo, Japan.
⁴ c Department of Surgical Pathology, Kumamoto University Medical School, Honjo, 1-1-1, Kumamoto.

PMID: 27463357
DOI: 10.3109/10428199109067640

Abstract

A patient previously treated for Hodgkin's disease (HD) developed secondary adult T cell leukaemia/lymphoma (ATL) after blood transfusion. Immunohistochemical analysis and polymerase chain reaction support the diagnosis. To the best of our knowledge this is the first occurrence of transfusion induced ATL occurring as a second malignancy after treatment for HD. The leukaemia/lymphoma probably developed on the basis of underlying immunosuppression.

Keywords: Blood transfusion-induced; Hodgkin's disease; adult T cell leukemia; adult T-cell lymphoma.