[The Therapeutic Dilemma in Treatment of Intracranial Infectious Aneurysm in Patients with Infective Endocarditis: Proposal for a Patient-Centered, Interdisciplinary Treatment Concept]

Fortschr Neurol Psychiatr. 2016 Jul;84(7):411-8. doi: 10.1055/s-0042-110850. Epub 2016 Jul 29.
[Article in German]

Abstract

Intracranial infectious aneurysms are rare but hazardous complications of an infective endocarditis. To date, there are no evidence-based recommendations for the treatment of patients with this condition. Therefore, it remains an interdisciplinary challenge to decide which treatment steps are required and in which order they should be carried out. To illustrate the interdisciplinary dilemma in the treatment of these patients, we here present a case of a 23-year-old, drug-addicted woman with infectious endocarditis. While antibiotic treatment of the streptococcus-mitis-induced endocarditis stabilized the overall status of the patient, rupture of a basilar artery aneurysm caused her sudden death. We discuss the decision-making processes of the treatment, potential difficulties and dilemmas when dealing with patients suffering from infectious endocarditis and infectious intracranial aneurysm. Based upon case reports, studies and reviews, we present the options and risks of conservative, neurosurgical, endovascular, and cardiosurgical treatment of intracranial infectious aneurysms, and propose a patient-centered, interdisciplinary treatment concept.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Algorithms
  • Aneurysm, Infected / complications*
  • Aneurysm, Infected / therapy*
  • Aneurysm, Ruptured / complications
  • Anti-Bacterial Agents / therapeutic use
  • Brain / pathology
  • Combined Modality Therapy
  • Diffusion Magnetic Resonance Imaging
  • Endocarditis, Bacterial / complications*
  • Endocarditis, Bacterial / therapy*
  • Fatal Outcome
  • Female
  • Humans
  • Interdisciplinary Communication*
  • Intersectoral Collaboration*
  • Intracranial Aneurysm / complications*
  • Intracranial Aneurysm / therapy*
  • Neurologic Examination
  • Patient-Centered Care*
  • Streptococcal Infections / complications*
  • Streptococcal Infections / therapy*
  • Streptococcus mitis*

Substances

  • Anti-Bacterial Agents