Production of scandium-43 and -47 from a powdery calcium oxide target via the (nat/44)Ca(α,x)-channel

Katsuyuki Minegishi; Kotaro Nagatsu; Masami Fukada; Hisashi Suzuki; Tomoyuki Ohya; Ming-Rong Zhang

doi:10.1016/j.apradiso.2016.07.017

Production of scandium-43 and -47 from a powdery calcium oxide target via the (nat/44)Ca(α,x)-channel

Appl Radiat Isot. 2016 Oct:116:8-12. doi: 10.1016/j.apradiso.2016.07.017. Epub 2016 Jul 20.

Authors

Katsuyuki Minegishi¹, Kotaro Nagatsu², Masami Fukada³, Hisashi Suzuki³, Tomoyuki Ohya³, Ming-Rong Zhang³

Affiliations

¹ Department of Radiopharmaceuticals Development, National Institutes for Quantum and Radiological Science and Technology (NIRS-QST), Japan; Neos-Tech, Co., Ltd., Japan.
² Department of Radiopharmaceuticals Development, National Institutes for Quantum and Radiological Science and Technology (NIRS-QST), Japan. Electronic address: [email protected].
³ Department of Radiopharmaceuticals Development, National Institutes for Quantum and Radiological Science and Technology (NIRS-QST), Japan.

PMID: 27472825
DOI: 10.1016/j.apradiso.2016.07.017

Abstract

We produced (43)Sc and (47)Sc via the (nat/44)Ca(α,x)-channel using a vertical beam coupled with a ceramic target box. After activation, the powdery CaO target material was dissolved in HCl in the target box in situ and remotely recovered as a radio-Sc solution. The respective yields of (43)Sc and (47)Sc following isolation via a precipitation method with a typical 0.22µm sterile filter were 54.8MBq/µAh (1.48mCi/µAh) and 780kBq/µAh (21.1µCi/µAh) at the end of separation (approximately 1.5h from the EOB). In addition, we discuss the recycling of target Ca.

Keywords: Ceramic target box; Sc-43; Sc-47; Sterile filter; Vertical irradiation.

Publication types

Research Support, Non-U.S. Gov't