Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA

Haematologica. 2016 Sep;101(9):e374-7. doi: 10.3324/haematol.2016.142323. Epub 2016 Jun 13.
No abstract available

Keywords: NOXA; chronic lymphocytic leukemia; oncomodulator.

Publication types

  • Letter

MeSH terms

  • Animals
  • Apoptosis Regulatory Proteins / physiology*
  • Disease Progression
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Myeloid Cell Leukemia Sequence 1 Protein / analysis
  • Proto-Oncogene Proteins / analysis
  • Proto-Oncogene Proteins c-bcl-2 / deficiency*
  • Proto-Oncogene Proteins c-bcl-2 / physiology
  • Receptors, Antigen, B-Cell

Substances

  • Apoptosis Regulatory Proteins
  • Mcl1 protein, mouse
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Pmaip1 protein, mouse
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Receptors, Antigen, B-Cell
  • Tcl1 protein, mouse