A route to new cancer therapies: the FA pathway is essential in BRCA1- or BRCA2-deficient cells

Nat Struct Mol Biol. 2016 Aug 3;23(8):701-3. doi: 10.1038/nsmb.3276.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • BRCA1 Protein / genetics
  • BRCA1 Protein / metabolism*
  • BRCA2 Protein / genetics
  • BRCA2 Protein / metabolism*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / physiopathology*
  • Breast Neoplasms / therapy
  • Fanconi Anemia Complementation Group D2 Protein / genetics
  • Fanconi Anemia Complementation Group D2 Protein / metabolism*
  • Female
  • Genetic Predisposition to Disease*
  • Humans
  • Mutant Proteins / genetics
  • Mutant Proteins / metabolism
  • Mutation*
  • Ovarian Neoplasms / genetics
  • Ovarian Neoplasms / physiopathology*
  • Ovarian Neoplasms / therapy

Substances

  • BRCA1 Protein
  • BRCA1 protein, human
  • BRCA2 Protein
  • BRCA2 protein, human
  • FANCD2 protein, human
  • Fanconi Anemia Complementation Group D2 Protein
  • Mutant Proteins