Who Put the "A" in ATP? Generation of ATP from ADP-Ribose in the Nucleus for Hormone-Dependent Gene Regulation

Keun Woo Ryu; W Lee Kraus

doi:10.1016/j.molcel.2016.07.018

Who Put the "A" in ATP? Generation of ATP from ADP-Ribose in the Nucleus for Hormone-Dependent Gene Regulation

Mol Cell. 2016 Aug 4;63(3):349-51. doi: 10.1016/j.molcel.2016.07.018.

Authors

Keun Woo Ryu¹, W Lee Kraus²

Affiliations

¹ Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Division of Basic Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: [email protected].

PMID: 27494555
DOI: 10.1016/j.molcel.2016.07.018

Abstract

In a recent issue of Science, Wright et al. (2016) describe a pathway for the synthesis of nuclear ATP, leading from NAD(+) to poly(ADP-ribose) to ADP-ribose to ATP, which supports the activity of ATP-dependent chromatin remodeling enzymes during hormone-dependent transcription.

Publication types

Comment

MeSH terms

Adenosine Diphosphate Ribose*
Adenosine Triphosphate
Cell Nucleus
NAD
Poly Adenosine Diphosphate Ribose
Poly(ADP-ribose) Polymerases*

Substances

NAD
Adenosine Diphosphate Ribose
Poly Adenosine Diphosphate Ribose
Adenosine Triphosphate
Poly(ADP-ribose) Polymerases