Leukocyte adhesion molecule dynamics after Natalizumab withdrawal in Multiple Sclerosis

Clin Immunol. 2016 Oct:171:18-24. doi: 10.1016/j.clim.2016.08.003. Epub 2016 Aug 3.

Abstract

Cell-adhesion molecules (CAMs) dynamics in Multiple Sclerosis (MS) patients have been widely studied after Natalizumab (NTZ) introduction. However, their temporal dynamics after NTZ withdrawal (NTZ-W) has not been described. We prospectively evaluate changes in the expression levels of CAMs (CD49d, CD29, L-Selectin and CD11a) involved in T cell migration of 22 MS patients after NTZ-W. CD49d, CD29 and CD11a expression experienced a continuous increase expression two months after NTZ-W and Cd49d expression at month six after NTZ-W correlated to NTZ treatment duration, both in CD45+CD4+ and CD45+CD8+. CD49d expression up to month three after NTZ-W was related to MS activity in CD45+CD8+ at the end of the study. Results from this study suggest that patients with a longer NTZ treatment are more susceptible to present a "molecular rebound" after NTZ-W. CD49d determination may be a useful tool to closely monitor MS activity in patients who interrupt NTZ.

Keywords: Adhesion molecules; Dynamics; Multiple Sclerosis; Natalizumab withdrawal; VLA-4.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Antigens, CD / immunology*
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Cell Adhesion Molecules / immunology*
  • Female
  • Humans
  • Immunologic Factors / pharmacology
  • Immunologic Factors / therapeutic use*
  • Integrin alpha4beta1 / immunology
  • Male
  • Middle Aged
  • Multiple Sclerosis / drug therapy*
  • Multiple Sclerosis / immunology
  • Natalizumab / pharmacology
  • Natalizumab / therapeutic use*
  • Young Adult

Substances

  • Antigens, CD
  • Cell Adhesion Molecules
  • Immunologic Factors
  • Integrin alpha4beta1
  • Natalizumab