Anti cytokine therapy in chronic inflammatory arthritis

Charlotte Thompson; Ruth Davies; Ernest Choy

doi:10.1016/j.cyto.2016.07.015

Anti cytokine therapy in chronic inflammatory arthritis

Cytokine. 2016 Oct:86:92-99. doi: 10.1016/j.cyto.2016.07.015. Epub 2016 Aug 3.

Authors

Charlotte Thompson¹, Ruth Davies², Ernest Choy³

Affiliations

¹ Department of Rheumatology, Institute of Infection and Immunity, Cardiff University School of Medicine, Tenovus Building, Heath Park Campus, Cardiff CF14 4XN, United Kingdom. Electronic address: [email protected].
² Department of Rheumatology, Institute of Infection and Immunity, Cardiff University School of Medicine, Tenovus Building, Heath Park Campus, Cardiff CF14 4XN, United Kingdom.
³ Department of Rheumatology and Translational Research, Institute of Infection and Immunity, Director of Arthritis Research UKCREATE Centre and Welsh Arthritis Research Network (WARN), Cardiff University School of Medicine, Tenovus Building, Heath Park Campus, Cardiff CF14 4XN, United Kingdom. Electronic address: [email protected].

PMID: 27497159
DOI: 10.1016/j.cyto.2016.07.015

Abstract

This is a review looking at anti cytokine therapy in Rheumatoid Arthritis (RA), Psoriatic Arthritis (PSA) and Ankylosing Spondylitis (AS). The review explores the similarities and differences in the clinical features, as well as treatments and cytokines involved in the development and propagation of the disease. Particular attention is paid to TNFα inhibitors IL-1ra, IL-6 and JAK kinase Inhibitors, anti IL23 and IL-12 and the new developments with anti-IL-17.

Keywords: Ankylosing Spondylitis; Cytokine; IL27; Inflammatory arthritis; Psoriatic Arthritis; Rheumatoid Arthritis; TNFα inhibitor.

Publication types

Review

MeSH terms

Animals
Arthritis, Psoriatic / drug therapy*
Arthritis, Psoriatic / immunology
Arthritis, Psoriatic / physiopathology
Arthritis, Rheumatoid / drug therapy*
Arthritis, Rheumatoid / immunology
Arthritis, Rheumatoid / physiopathology
Chronic Disease / drug therapy
Cytokines / antagonists & inhibitors*
Cytokines / metabolism
Humans
Interleukin 1 Receptor Antagonist Protein / therapeutic use
Interleukin-12 / antagonists & inhibitors
Interleukin-17 / antagonists & inhibitors
Interleukin-23 / antagonists & inhibitors
Interleukin-27 / antagonists & inhibitors
Interleukin-6 / therapeutic use
Janus Kinases / antagonists & inhibitors
Mice
Spondylitis, Ankylosing / drug therapy*
Spondylitis, Ankylosing / immunology
Spondylitis, Ankylosing / physiopathology
Tumor Necrosis Factor-alpha / antagonists & inhibitors

Substances

Cytokines
IL6 protein, human
Interleukin 1 Receptor Antagonist Protein
Interleukin-17
Interleukin-23
Interleukin-27
Interleukin-6
Tumor Necrosis Factor-alpha
Interleukin-12
Janus Kinases