Herpes virus reactivation after initiation of interferon-free antiviral agents in HIV-HCV-coinfected subjects: a new immune restoration disease?

Raffaella Marocco; Miriam Lichtner; Tiziana Tieghi; Irene Pozzetto; Claudio M Mastroianni

doi:10.3851/IMP3072

Herpes virus reactivation after initiation of interferon-free antiviral agents in HIV-HCV-coinfected subjects: a new immune restoration disease?

Antivir Ther. 2016;21(8):739-742. doi: 10.3851/IMP3072. Epub 2016 Aug 8.

Authors

Raffaella Marocco¹, Miriam Lichtner¹, Tiziana Tieghi¹, Irene Pozzetto¹, Claudio M Mastroianni¹

Affiliation

¹ Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University, Polo Pontino, Latina, Italy.

PMID: 27501112
DOI: 10.3851/IMP3072

Abstract

We report four HCV-HIV-coinfected patients who developed herpes zoster or muco-cutaneous herpes virus disease shortly after starting interferon-free antiviral treatment for HCV. We suggest that in our patients the prompt clearance of HCV following direct-acting antivirals leads to a paradoxical effect on the innate and adaptive immune system mediating the reactivation of herpetic infection.

Publication types

Case Reports

MeSH terms

Adult
Antiviral Agents / therapeutic use*
Coinfection / drug therapy*
Coinfection / immunology
Female
HIV Infections / drug therapy*
HIV Infections / immunology
HIV Infections / virology
Hepatitis C, Chronic / drug therapy*
Hepatitis C, Chronic / immunology
Hepatitis C, Chronic / virology
Herpesvirus 3, Human / drug effects*
Herpesvirus 3, Human / physiology
Humans
Male
Middle Aged
Simplexvirus / drug effects*
Simplexvirus / physiology
Virus Activation / drug effects*

Substances

Antiviral Agents