Dual targeting of Hsp90 in childhood acute lymphoblastic leukaemia

Br J Haematol. 2018 Jan;180(1):147-149. doi: 10.1111/bjh.14275. Epub 2016 Aug 9.
No abstract available

Keywords: Hsp90; NSG mice; acute lymphoblastic leukaemia; leukaemia-initiating cells; toxicity.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Benzoquinones / pharmacology
  • Cell Survival / drug effects
  • Child
  • Dose-Response Relationship, Drug
  • HSP90 Heat-Shock Proteins / antagonists & inhibitors
  • HSP90 Heat-Shock Proteins / metabolism*
  • Humans
  • Lactams, Macrocyclic / pharmacology
  • Molecular Targeted Therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
  • Signal Transduction / drug effects

Substances

  • Antineoplastic Agents
  • Benzoquinones
  • HSP90 Heat-Shock Proteins
  • Lactams, Macrocyclic
  • 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin