In Vitro Activity of 3-Triazeneindoles against Mycobacterium tuberculosis and Mycobacterium avium

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6422-4. doi: 10.1128/AAC.00998-16. Print 2016 Oct.

Abstract

Among 230 target-synthesized indole-based compounds, seven 3-triazenoindoles showed MICs of 0.2 to 0.5 μg/ml against Mycobacterium tuberculosis strain H37Rv and isoniazid-resistant human isolate CN-40. The TU112 compound was active also against a dormant form of M. tuberculosis Some of these triazenoindoles were active against Mycobacterium avium, with MICs of 0.05 to 0.5 μg/ml. The selectivity indices (SI) for M. tuberculosis and M. avium were significantly higher than 10, making these compounds acceptable for the next testing step.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / chemistry
  • Antitubercular Agents / pharmacology*
  • Drug Evaluation, Preclinical / methods
  • Drug Resistance, Bacterial / drug effects
  • Humans
  • Indoles / chemistry
  • Indoles / pharmacology
  • Isoniazid / pharmacology
  • Microbial Sensitivity Tests
  • Mycobacterium avium / drug effects*
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / isolation & purification

Substances

  • Antitubercular Agents
  • Indoles
  • Isoniazid