Elucidating the anti-Staphylococcus aureus antibody response by immunoproteomics

Proteomics Clin Appl. 2016 Oct;10(9-10):1011-1019. doi: 10.1002/prca.201600050.

Abstract

Staphylococcus aureus is a notorious pathogen both in- and outside hospitals as well as a frequent colonizer in healthy individuals. Immunoproteomics techniques have been employed to shed light on the human adaptive immune response to S. aureus in health and disease. Since priming of immune memory, a key property of the adaptive immune system, is the basis of successful vaccination, immunoproteomics holds promise for paving the way to an effective S. aureus vaccine.

Keywords: 1D immunoblots; 2D immunoblots; Antibacterial antibodies; Protein array; Suspension array.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Bacterial / immunology*
  • Antibodies, Bacterial / metabolism*
  • Antigens, Bacterial / immunology
  • Bacterial Vaccines / immunology
  • Host-Pathogen Interactions / immunology*
  • Humans
  • Proteomics / methods*
  • Staphylococcus aureus / immunology*

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Vaccines